Bacillus is often used in aquaculture, there are many different types, including: subtilis, lichens, laterosporus, etc., of which the Bacillus subtilis is the most common.

liver development phase of white shrimps means dietary change, and poor intestinal function can lead to hepatopancreas dysplasia and even death  

What are the factors that affect the efficacy of EM bacteria?

As no adverse response was seen when C.butyricum was included in diets at 100 times the recommended dose, the FEEDAP Panel concludes that the product is safe for chickens for fattening at the recommended dose.

Miyarisan has sold preparations of CBM 588 in Japan and other Asian countries for both human and animal use since the 1960s with no adverse events or reports of allergenicity (Confidential Annex 2). Published in vitro and in vivo data and a long history of safe use in humans in Asian countries help support CBM 588 as a safe strain for use in food supplements in the EU (e.g. Confidential Annex 4; Fujita et al 1986; Fujita & Takashi, 1986, 1987; Imase et al 2008; Ito et al 1997; Kamiya et al 1997; Kitajo et al 1990, 1991; Kobashi et al 1983, 1976; Kobayashi et al 1976; Kurata et al 1988; Kuroiwa et al 1990a, 1990b; Maebashi et al 1998; Nakatsuji et al 1995; Okabayashi & Kobari 1994; Seki et al 2003; Shimbo et al 2005; Taguchi et al 1988; Takahashi et al 2000, 2004; Takeda et al 1976, 1983, Yuzawa et al 1987a, b, c; Zhang et al 1998).

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