The gut fights in very front-line defending the health, its barrier functions are important shields to keep out the pathogens and other harmful substance. Lets see how Clostridium butyricum can contribute to these barriers. First is physical barrier, Clostridium butyricum induces the expression of tight junction protein gene, enhance the connection between cells, reduce cell permeability, regulate the apoptosis process of epithelial cell and effectively protect the integrity of intestine. Second is the chemical barrier, Clostridium butyricum promotes the secretion of antimicrobial and defensive substance by the epithelial cells; Clostridium butyricum also adhere to epithelial cells to stimulate the secretion of mucin, which forms a protective layer between intestinal mucosa and pathogens; moreover, Clostridium butyricum produces vast  organic acids, reduce the pH to create an acidic environment which is very friendly for good bacteria but not friendly for the bad ones.

Probiotics is not feed, but can improve digestion and absorption of feed; its not medicine, but can prevent, control and treat diseases. Probiotics has both biological function of medicine and nutrient composition of feed. Nowdays, probiotic solutions are becoming more and more accepted by the animal farming all around the world, some regions earlier than others, the trend is very clear, the prospects of probiotic is very promising. In my next video, I will talk about a rising super star in probiotic family - Clostridium Butyricum, to explore   its outstanding features and what it can do to make animal farming easier.

probiotic is in fact compatible with antibiotics, for example, probioitcs help animals quickly back to health and recover from side effects caused by antibiotics, they can work along, not together, but taking turns, normally few days gap. So, using antibiotics sometimes would be a necessary solution but probiotic is truly a better way.  I have listed some key differences for probiotics and antibiotics, so we will have a clear understanding of the idea.

A healthy intestine means having good digestive function, complete structure, good barrier function, stable mircoflora and efficient immune system. These factors are interrelated and interact with each other like teamwork.

First of all, it's ture that nothing can replace anything; It is very significant that the advantages, efficacy, mechanism and the changes brought by antibiotics to our lives.

Bacillus is often used in aquaculture, there are many different types, including: subtilis, lichens, laterosporus, etc., of which the Bacillus subtilis is the most common.

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