Clostridium butyricum is a kind of butyric-producing gram-positive anaerobic bacteria of Clostridium genus in the Bacillus genus. Clostridium butyricum is a strict anaerobic bacterium, which can fully adapt to the anaerobic environment of animal intestinal tract and regulate the balance of intestinal flora in various ways. Clostridium butyricum can produce a large amount of butyric acid in the intestine, especially in the posterior part of the intestine. Butyric acid is the energy source of intestinal cells and plays an important role in the regeneration and repair of intestinal epithelial tissue.


Clostridium butyricum produces antibacterial peptide, which kills harmful bacteria such as Clostridium perfringens and effectively prevents necrotizing enteritis. Clostridium butyricum can produce a large number of endogenous enzymes, which can carry out secondary digestion and utilize the residual nutrients in the intestine. Clostridium butyricum can be generated in the process of proliferation of folic acid and other nutrients, can be generated to resist, indole substances such as bacteria activity, reduce the amount of protein to the amine and ammonia conversion, part can inhibit the microbial urease activity, reduce nitrogen emissions in the faeces and urine and reducing of feces stink, improve the breeding environment. It can change the intestinal flora structure of pigs, maintain the integrity of intestinal barrier, activate immunity, improve digestion and promote growth. In poultry application, adding Clostridium butyricum into the diet can not only improve the daily gain and feed conversion rate of broilers, improve the intestinal microflora structure and barrier function, but also effectively prevent the occurrence of enteritis, improve the immunity of broilers, promote the growth and improve the quality of chicken.


Clostridium butyricum is a kind of new microbial feed additive, which has the advantages of lactic acid bacteria and bacillus. It is resistant to gastric acid, digestive enzyme, bile acid and antibiotics.


Clostridium butyricum and other microecological agents are more and more widely used, and show an unlimited application prospect. Major manufacturers of clostridium butyricum include: AOR Canada, MiyarisanPharmaceutical Co., Ltd , MITUSHI BIOPHARMA . In 1940, Clostridium butyricum was commercialized in Japan and used clinically. In 2003, The European Union approved clostridium butyricum as a feed additive for broiler chickens and weaned piglets. Production process of Clostridium butyricum as biological feed additive of Henan Jinbaihe Biotechnology Co., LTD : Clostridium butyricum as feed additive is made of clostridium butyricum by liquid fermentation and filling or by liquid fermentation and drying or by adding crushed natural plants (astragalus membranaceus, Acanthoacanthus acanthoacanthus) by solid fermentation and drying.


In the aspect of animal husbandry, with the steady development of animal husbandry and the acceleration of the process of non-resistant breeding, the application of clostridium butyricum and other microecological agents is more and more extensive, and shows an unlimited application prospect.


Practice has proved that clostridium butyricum with other probiotics, herbal extracts, such as a combination, can correct the animal intestinal disorders, reduce the occurrence of enterotoxin, enhance the body's immune function, can secrete a variety of enzymes and vitamins, effectively promote digestion and absorption of nutrients, have the effect of eliminate inflammation, nutrition, the intestinal tract, application effect is remarkable.


As a new kind of green microecological preparation, especially in the background without anti-breeding, Clostridium butyricum preparation has a very wide application prospect and a large demand market .


The application of Clostridium butyricum can increase the utilization efficiency of animal feed by 3% ~ 5%, and it is estimated that 6,000-12,000 tons of breeding feed can be saved. Due to Clostridium butyricum with the intestinal adjustment, anti-inflammatory and promote animal to grow, and so on, used as feed additives, do not contain any additives, no drugs and harmful substances, can be used in the production of green animal products, so will be applied in livestock and poultry breeding animals such as butyric acid bacteria, can realize farmers control disease to save money, energy conservation and emissions reduction and efficiency, to ensure the safety of food, promote the healthy and sustainable development of aquaculture industry has significant social benefits.