The Clostridium butyricum of JBH is well known and used by everyone for its physiological functions such as effective regulation of intestinal health, balance of intestinal flora and improvement of immune performance. In fact, in the application and promotion of Clostridium butyricum, its excellent resistance to stress is an important element that distinguishes it from many probiotic preparations. The protection of the resistance of Clostridium butyricum is based on the formation of endophytic spores, which can allow Clostridium butyricum to resist various extreme environments, and re-germinate and proliferate in a suitable environment to play a key physiological role. And today, from the formation of spores and the composition of spores, we will decipher the "trump card" of the resistance of Clostridium butyricum

"Golden Bell Jar"-Endophytic spores with spores changing around the world

Prokaryotes usually form two identical daughter cells through secondary fission to achieve cell proliferation. However, some prokaryotes use alternative developmental processes to produce daughter cells with different cell morphologies and fates to achieve cell state transformation. Like other bacillus, Clostridium butyricum can form endospores. Generally, a series of electron microscopy images obtained from spore-forming Clostridium cells is similar to the stage found in Clostridium acetobutylicum. Clostridium butyricum actively activates a variety of survival mechanisms based on changes in the external environment, such as motility, uptake of foreign DNA, formation of biofilms, and spore formation. The main purpose of spore formation is to produce a dormant cell that is largely inactive in metabolism. It can survive in harsh environmental conditions until it restores favorable growth conditions, germinates and restores its vegetative cell cycle. The spore formation of Bacillus subtilis first undergoes an asymmetrical division, and then a "polar separation" is formed in the two parts that split out, separating two different sections, a larger "mother cell" and a smaller "prespore" body". This asymmetrical division also created different development directions in the follow-up. The spore precursor squeezes the polar septum and the membrane structure of the mother cell inward, and is finally surrounded by the mother cell membrane structure, forming a process in which the mother cell engulfed the spore precursor. After phagocytosis is completed, the spore precursor forms a spherical structure similar to an organelle in the cytoplasm of the mother cell, and then the spore precursor matures and becomes a partially dehydrated dormant cell. The outer mother cell is programmed to lyse, and finally mature spores are formed. Release into the environment.

"Iron cloth shirt"-practice the tibia skin outside and the spore structure of one breath inside

In addition to the golden bell hood stunts of Clostridium butyricum that can spores in the world, another thing that makes it "break through the martial arts" is its layered protection of spore structure, which is the resistance of Clostridium butyricum in terms of form and content. It has been greatly improved. The structure of Clostridium butyricum is exosporium, spore coat, cortex and spore cell wall in order from outside to inside. The structure of these walls is to protect the "heart" of Clostridium butyricum, which is the protoplast in the spore wall, also called the core. These cladding structures are not simple. First, the outer spore wall can be structurally protected to resist some physical damage from the outside; the second line of defense spore coat is extremely dense in texture, making it impermeable. Some chemicals that attack Clostridium butyricum through osmotic means are helpless; the second layer is the cortex, which can rob the core of moisture through osmosis, and lose the core of moisture. It is stronger than ever and can be protected from heat and radiation. If you feel that the core protected by these layers is fragile, then you are wrong. There is a chemical substance of 2,6-dipicolinic acid in the core of Clostridium butyricum, which can form a stable complex with calcium ions, which can greatly improve the resistance to heat and other lethal factors.

Practice is the only criterion for testing truth. Therefore, we have never stopped to verify the stability of Clostridium butyricum. Among the main environmental challenges in the feed industry and the digestive physiological conditions of livestock and poultry, they mainly focus on the challenges of high temperature environment, low pH environment, high bile salt environment, and long-term storage environment. The Clostridium butyricum of Golden Lily Biology can still maintain good activity in a variety of adverse environments, with outstanding quality and trustworthy.